- Any MLH1, MSH2, MSH6, PMS2 mutation identified on tumor genomic profiling
- Any reported germline incidental finding (Tempus)
- When somatic findings and family history match a hereditary cancer syndrome
- All MSI high tumors
- Refer based on personal or family history indication regardless of somatic results
- i.e. Early age of diagnosis (<50: colon, uterine)
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